Kinetics and in vivo distribution of in-111-labelled platelets and platelet function in familial hypercholesterolaemia.
Identifieur interne : 005F60 ( Main/Exploration ); précédent : 005F59; suivant : 005F61Kinetics and in vivo distribution of in-111-labelled platelets and platelet function in familial hypercholesterolaemia.
Auteurs : RBID : pubmed:3433247English descriptors
- KwdEn :
- MESH :
- chemical : Indium Radioisotopes.
- blood : Arteriosclerosis, Hyperlipoproteinemia Type II.
- complications : Arteriosclerosis, Hyperlipoproteinemia Type II.
- physiology : Blood Platelets.
- Adult, Cell Survival, Humans, Kinetics, Male, Middle Aged, Platelet Aggregation.
Abstract
The kinetics, in vivo distribution and sites of sequestration of autologous In-111-labelled platelets and other platelet function parameters were studied in ten patients with type IIa or IIb familial hypercholesterolaemia and thrombotic complications of atherosclerosis. The in vitro platelet aggregation response to ADP (P = 0.50) and collagen (P = 0.46); binding of fibrinogen to platelets (P = 0.61); and plasma beta-thromboglobulin levels (P = 0.42) of the patients and normal reference subjects did not differ significantly. The in vivo distribution of In-111-labelled platelets at equilibrium was within normal limits, and at the end of platelet life-span the sequestration pattern of labelled platelets in the reticuloendothelial system was also normal (spleen P = 0.31; liver P = 0.54). There was minimal evidence of in vivo platelet activation: only mean platelet lifespan (MPLS), 195 +/- 57 hours (difference between mean MPLS of patients and controls was 25 hours, with a 95% confidence interval from 23 to 31 hours; P = 0.02); mean platelet platelet turnover, 2298 +/- 824 platelets/microliter/hour (P = 0.005); plasma platelet factor 4 (P = 0.02); and the mean circulating platelet aggregate ratio, 0.8 +/- 0.1 (P = 0.02); differed significantly from normal. These results suggest that abnormalities of platelet function and kinetics observed in type II hyperlipoproteinaemia cannot be ascribed wholly to the hyperlipidaemia, but may be induced by the associated atherosclerosis.
PubMed: 3433247
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Kinetics and in vivo distribution of in-111-labelled platelets and platelet function in familial hypercholesterolaemia.</title><author><name sortKey="Wessels, P" uniqKey="Wessels P">P Wessels</name><affiliation wicri:level="1"><nlm:affiliation>MRC Blood Platelet Research Unit, University of the Orange Free State, Bloemfontein, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>MRC Blood Platelet Research Unit, University of the Orange Free State, Bloemfontein</wicri:regionArea></affiliation></author><author><name sortKey="Heyns, A D" uniqKey="Heyns A">A D Heyns</name></author><author><name sortKey="Esterhuysen, A J" uniqKey="Esterhuysen A">A J Esterhuysen</name></author><author><name sortKey="Badenhorst, P N" uniqKey="Badenhorst P">P N Badenhorst</name></author><author><name sortKey="L Tter, M G" uniqKey="L Tter M">M G Lötter</name></author><author><name sortKey="Pieters, H" uniqKey="Pieters H">H Pieters</name></author><author><name sortKey="Kotze, H F" uniqKey="Kotze H">H F Kotzè</name></author></titleStmt><publicationStmt><date when="1987">1987</date><idno type="RBID">pubmed:3433247</idno><idno type="pmid">3433247</idno><idno type="wicri:Area/Main/Corpus">006285</idno><idno type="wicri:Area/Main/Curation">006285</idno><idno type="wicri:Area/Main/Exploration">005F60</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Arteriosclerosis (blood)</term><term>Arteriosclerosis (complications)</term><term>Blood Platelets (physiology)</term><term>Cell Survival</term><term>Humans</term><term>Hyperlipoproteinemia Type II (blood)</term><term>Hyperlipoproteinemia Type II (complications)</term><term>Indium Radioisotopes</term><term>Kinetics</term><term>Male</term><term>Middle Aged</term><term>Platelet Aggregation</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Indium Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Arteriosclerosis</term><term>Hyperlipoproteinemia Type II</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Arteriosclerosis</term><term>Hyperlipoproteinemia Type II</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Platelets</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cell Survival</term><term>Humans</term><term>Kinetics</term><term>Male</term><term>Middle Aged</term><term>Platelet Aggregation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The kinetics, in vivo distribution and sites of sequestration of autologous In-111-labelled platelets and other platelet function parameters were studied in ten patients with type IIa or IIb familial hypercholesterolaemia and thrombotic complications of atherosclerosis. The in vitro platelet aggregation response to ADP (P = 0.50) and collagen (P = 0.46); binding of fibrinogen to platelets (P = 0.61); and plasma beta-thromboglobulin levels (P = 0.42) of the patients and normal reference subjects did not differ significantly. The in vivo distribution of In-111-labelled platelets at equilibrium was within normal limits, and at the end of platelet life-span the sequestration pattern of labelled platelets in the reticuloendothelial system was also normal (spleen P = 0.31; liver P = 0.54). There was minimal evidence of in vivo platelet activation: only mean platelet lifespan (MPLS), 195 +/- 57 hours (difference between mean MPLS of patients and controls was 25 hours, with a 95% confidence interval from 23 to 31 hours; P = 0.02); mean platelet platelet turnover, 2298 +/- 824 platelets/microliter/hour (P = 0.005); plasma platelet factor 4 (P = 0.02); and the mean circulating platelet aggregate ratio, 0.8 +/- 0.1 (P = 0.02); differed significantly from normal. These results suggest that abnormalities of platelet function and kinetics observed in type II hyperlipoproteinaemia cannot be ascribed wholly to the hyperlipidaemia, but may be induced by the associated atherosclerosis.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">3433247</PMID><DateCreated><Year>1988</Year><Month>03</Month><Day>16</Day></DateCreated><DateCompleted><Year>1988</Year><Month>03</Month><Day>16</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0340-6245</ISSN><JournalIssue CitedMedium="Print"><Volume>58</Volume><Issue>3</Issue><PubDate><Year>1987</Year><Month>Oct</Month><Day>28</Day></PubDate></JournalIssue><Title>Thrombosis and haemostasis</Title><ISOAbbreviation>Thromb. Haemost.</ISOAbbreviation></Journal><ArticleTitle>Kinetics and in vivo distribution of in-111-labelled platelets and platelet function in familial hypercholesterolaemia.</ArticleTitle><Pagination><MedlinePgn>811-6</MedlinePgn></Pagination><Abstract><AbstractText>The kinetics, in vivo distribution and sites of sequestration of autologous In-111-labelled platelets and other platelet function parameters were studied in ten patients with type IIa or IIb familial hypercholesterolaemia and thrombotic complications of atherosclerosis. The in vitro platelet aggregation response to ADP (P = 0.50) and collagen (P = 0.46); binding of fibrinogen to platelets (P = 0.61); and plasma beta-thromboglobulin levels (P = 0.42) of the patients and normal reference subjects did not differ significantly. The in vivo distribution of In-111-labelled platelets at equilibrium was within normal limits, and at the end of platelet life-span the sequestration pattern of labelled platelets in the reticuloendothelial system was also normal (spleen P = 0.31; liver P = 0.54). There was minimal evidence of in vivo platelet activation: only mean platelet lifespan (MPLS), 195 +/- 57 hours (difference between mean MPLS of patients and controls was 25 hours, with a 95% confidence interval from 23 to 31 hours; P = 0.02); mean platelet platelet turnover, 2298 +/- 824 platelets/microliter/hour (P = 0.005); plasma platelet factor 4 (P = 0.02); and the mean circulating platelet aggregate ratio, 0.8 +/- 0.1 (P = 0.02); differed significantly from normal. These results suggest that abnormalities of platelet function and kinetics observed in type II hyperlipoproteinaemia cannot be ascribed wholly to the hyperlipidaemia, but may be induced by the associated atherosclerosis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wessels</LastName><ForeName>P</ForeName><Initials>P</Initials><Affiliation>MRC Blood Platelet Research Unit, University of the Orange Free State, Bloemfontein, South Africa.</Affiliation></Author><Author ValidYN="Y"><LastName>Heyns</LastName><ForeName>A D</ForeName><Initials>AD</Initials></Author><Author ValidYN="Y"><LastName>Esterhuysen</LastName><ForeName>A J</ForeName><Initials>AJ</Initials></Author><Author ValidYN="Y"><LastName>Badenhorst</LastName><ForeName>P N</ForeName><Initials>PN</Initials></Author><Author ValidYN="Y"><LastName>Lötter</LastName><ForeName>M G</ForeName><Initials>MG</Initials></Author><Author ValidYN="Y"><LastName>Pieters</LastName><ForeName>H</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Kotzè</LastName><ForeName>H F</ForeName><Initials>HF</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>In Vitro</PublicationType><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>GERMANY, WEST</Country><MedlineTA>Thromb Haemost</MedlineTA><NlmUniqueID>7608063</NlmUniqueID><ISSNLinking>0340-6245</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Arteriosclerosis</DescriptorName><QualifierName MajorTopicYN="N">blood</QualifierName><QualifierName MajorTopicYN="N">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Blood Platelets</DescriptorName><QualifierName MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cell Survival</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Hyperlipoproteinemia Type II</DescriptorName><QualifierName MajorTopicYN="Y">blood</QualifierName><QualifierName MajorTopicYN="N">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Kinetics</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Platelet Aggregation</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1987</Year><Month>10</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1987</Year><Month>10</Month><Day>28</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1987</Year><Month>10</Month><Day>28</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">3433247</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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